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Coxiella burnetii: Recent Advances and New Perspectives in Research of the Q Fever Bacterium

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Coxiella burnetii: Recent Advances and New Perspectives in Research of the Q Fever Bacterium

Robert A. Heinzen, Jean-Louis Mege, James E. Samuel, Rudolf Toman

Springer
Publication date : 2012-06-19

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Coxiella burnetii is the etiological agent of Q fever, a zoonotic disease found worldwide. The bacterium is a fascinating example of intracellular parasitism that has uniquely evolved to thrive in the most inhospitable of cellular compartments-the phagolysosome. Understanding how C. burnetii resists the degradative functions of this vacuole, and the host cell functions coopted for successful parasitism, are central to understanding Q fever pathogenesis. Recent achievements in glycomics and proteomics are guiding development of enhanced detection schemes for the bacterium in addition to shedding light on the host immune response to the pathogen. Several chapters survey immune functions that control or potentially exacerbate Coxiella infection and delve into correlates of protective immunity elicited by vaccination. Comparative genomics is also the foundation of chapters discussing diagnostic antigen discovery and molecular typing of the bacterium, with significance for development of new clinical, epidemiologic, and forensic tools.

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About the book

Author

Robert A. Heinzen , Jean-Louis Mege , James E. Samuel , Rudolf Toman

Imprint

Springer

Collection

n.c

Publication date

2012-06-19

Pages

406 pages

Print ISBN

9789400743144

Language

English

Ebook informations

EAN EPUB

9789400743151

Price

£179.50

Copy count 4

Print count 40

File size 2509 Ko

Informations accessibility

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About author(s)

Robert A. Heinzen

Jean-Louis Mege

James E. Samuel

Rudolf Toman

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