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Structural and Biochemical Characterization of the YaxAB Pore-forming Toxin from Yersinia Enterocoli...

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Structural and Biochemical Characterization of the YaxAB Pore-forming Toxin from Yersinia Enterocolitica

Bastian Bräuning

Springer
Collection: Springer Theses
Publication date : 2019-09-26

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This book discusses the decoding of the lytic mechanism of an a-helical pore-forming toxin, YaxAB, composed of two different subunits. Pore-forming toxins (PFTs) are among the most common bacterial toxins. They are produced by a variety of pathogens, which infect a wide range of organisms including plants, insects and humans. Yet the maturation of these particles and the structural changes required for pore formation are still poorly understood for many PFT families.

Using a diverse panel of biochemical and structural techniques, including X-ray crystallography and cryo-electron microscopy, Dr. Bräuning and colleagues have succeeded in identifying the mechanistic contributions of the two toxin components and elucidating the lytic state of the pore complex. The results of this thesis on the YaxAB system are applicable to orthologues from agriculturally relevant insect pathogens, and offer valuable structural and mechanistic insights to inform future bioengineering efforts.

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About the book

Author

Bastian Bräuning

Imprint

Springer

Collection

Springer Theses

Publication date

2019-09-26

Pages

86 pages

Print ISBN

9783030294380

Language

English

Ebook informations

EAN PDF

9783030294397

Price

£89.50

Copy count 0

Print count 8

File size 5888 Ko

Informations accessibility

EAN EPUB

9783030294397

Price

£89.50

Copy count 0

Print count 8

File size 33823 Ko

Informations accessibility

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About author(s)

Bastian Bräuning

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