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Impact, Progress and Challenges of Lyophilization
Louise Reader
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The book presents a comprehensive summary of the advances in methods, applications and challenges in Freeze-drying Technology for pharmaceutical product development.
Freeze drying, sometimes referred to as lyophilization, is an essential method in biomedical and pharmaceutical industries that allows for extremely accurate preservation of sensitive biological components. This book highlights freeze drying operation, the different types of freeze-dryers, development of the freeze-drying cycle, and characterization of freeze-dried goods. It also explores the crucial connection between freeze drying and colloidal dispersions' stability, illuminating the complex interactions between formulation composition, processing variables, and stability of the final product. It focuses on the benefits of this method for stabilizing essential biopharmaceuticals such as probiotics, recombinant proteins and monoclonal antibodies by preventing aggregation and degradation and sustaining their therapeutic effectiveness for longer periods of time. Apart from the chemistry, operations and benefits, this book explores new possibilities for precisely and deeply describing freeze-dried products by discussing the most recent developments in analytical methods.
The audience for this book will comprise of researchers, clinicians, graduate students, and professionals in biotechnology and pharmaceutical industries. This book also serves as a valuable resource for educators by providing them information that they can incorporate into their curricula for teaching pharmaceutical formulation and drug delivery.
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Dalapathi Gugulothu is working as an Assistant Professor at the Delhi Institute of Pharmaceutical Sciences and Research (DIPSAR), under the Delhi Pharmaceutical Sciences and Research University (DPSRU), New Delhi. His research interests include siRNA delivery, nanotoxicology, targeted drug delivery systems, nanofibers, exosomes, gastroretentive drug delivery systems, orodispersible drug delivery systems, and lyophilization cycle development.
He has presented numerous research papers at various national and international conferences and has received multiple Best Research Paper awards. He has been granted three Indian patents. He has published more than 30 review and research papers and contributed 20 chapters in various books. He is also the author of the book Exosome Communication: Advances in Research and Therapeutics for Health and Disease. He has successfully completed one research project sponsored by SERB-DST, and another SERB-DST-funded project is currently ongoing. Recently, he also received a project from CCRUM as a Co-Principal Investigator. Furthermore, he has been awarded travel grants from both DBT and DST for attending international conferences.
Sumit Sharma has received his PhD degree from University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, India. He is having both pharmaceutical industry and academic experience in research of 12 years. Currently he is an Assistant Professor in School of Pharmaceutical Sciences, Delhi Pharmaceutical Sciences and Research University, and his research mainly focuses on sterile formulations for injectables and ophthalmics, materials science, colon targeted drug delivery, multi-unit particulate systems, stimuli responsive, gelling systems, suspensions, tablets, film coating techniques, pharmacokinetics, and bio-analytical techniques. He has 43 peer-reviewed publications (26 research papers and 17 international book chapters) and is a co-inventor in 6 patent applications. Recently he received a research project under E-YUVA scheme funded by Biotechnology Industry Research Assistance Council (BIRAC) in 2024.
Meenakshi Kanwar Chauhan is working as Associate Professor in the Department of Pharmaceutics, Delhi Institute of Pharmaceutical Sciences and Research, DPSR-University, New Delhi, India. She has received her MPharm and PhD degrees from UIPS, Panjab University, Chandigarh, India. She has a total of 23 years of experience in teaching and research. She has been ranked among the top 2% of the world's scientists in Stanford University's prestigious 2022 global list. She has been granted one Indian Patent. She has published more than 94 research papers in high-impact factor Scopus-indexed reputed international journals with h-index 18 and i10 index-24 and has more than 1972 Google scholar citations. Her research paper entitled “Natural gums and modified natural gums as sustained-release carriers” has received more than 500 citations. The research work has been presented at 104 national and international conferences, of which 13-research works have won best poster/oral presentation awards. She has been conferred the Women Researcher Award by the Association of Vdgood Professional at 9th International Scientist Awards on Engineering, Science, and Medicine, Trichy, in 2020. She has been granted the Most Dedicated Training Placement Officer Award by the Golden AIM Conference and Awards for Excellence & Leadership in Healthcare Education and E-Learning in 2020. She has also been honored with the Appreciation Award as Faculty Coordinator for the MANAV Scientific Reading and Comprehension Self-Assessment Module and Mentoring the students. She has so far supervised 7 (3 supervising) PhD and 49 master students. She has managed projects worth more than Rs. 80 lakhs funded by various government funding agencies (ICMR, DST, INMAS, DRDO, and AICTE). Her research interests are the development of intelligent and nano-based noninvasive drug delivery systems for targeting various ocular disorders and novel drug delivery approaches for neurological disorders such as Parkinson’s disease, Alzheimer’s disease, and Dementia.
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