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Autoimmune diseases represent a significant and complex global health burden, particularly among women, yet their underlying causes remain only partially understood. Affecting nearly every organ system, these conditions are driven by intricate interactions between genetic susceptibility, epigenetic modifications, and environmental triggers such as viral infections and toxins. With over 80 distinct autoimmune disorders identified—ranging from systemic to organ-specific—diagnosis and treatment continue to pose substantial clinical challenges. Despite progress in identifying autoantibodies and disease mechanisms, current therapies fall short of inducing long-term immune tolerance or preventing disease progression. This book offers a comprehensive exploration of the latest research into the molecular, genetic, and cellular underpinnings of autoimmune disease pathogenesis. It presents emerging therapeutic approaches grounded in advanced computational modeling, systems biology, and bioinformatics, as well as the design of novel bioactive compounds. A particular focus is placed on next-generation, nanoparticle-based drug delivery systems that promise to transform the treatment landscape by enhancing targeting specificity and minimizing systemic side effects. With in-depth coverage of Rheumatoid Arthritis (RA), Type 1 Diabetes (T1D), and Multiple Sclerosis (MS), this volume serves as a critical resource for specialists, researchers, and clinicians seeking to deepen their understanding of autoimmune disease mechanisms and therapeutic innovation. Through interdisciplinary insights and a forward-looking perspective, the book aims to accelerate the development of precision treatments that can significantly improve patient outcomes and quality of life.
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Prof. Young Ok Son is a distinguished researcher and educator specializing in cell biology and molecular biochemistry. At Jeju National University, his research focuses on utilizing bioactive compounds derived from Jeju’s rich biodiversity to develop innovative disease control models. His work targets key arthritis-associated genes, including HIF2α, ZIP8, ERRγ, and ZFP36L1, with the aim of identifying natural inhibitors and advancing novel therapeutic strategies for arthritis. As Director of the Practical Translational Research Center and Associate Professor in the Department of Animal Biotechnology, Prof. Son plays a central role in interdisciplinary research initiatives. He also serves as an Adjunct Professor in the Interdisciplinary Graduate Program in Advanced Convergence Technology and Science. His exceptional contributions to education and research have earned him numerous accolades, including the Outstanding Faculty Award for Excellence in Thesis Advising (Ph.D course, 2025) and the Best Professor for Research (2023). Prof. Son is a multiple recipient of the JNU BK-Honor Award for Professor (2025), as well as the JNU Rising BK-Honor Award for Professor (2023, 2022), and has also been recognized with the Best Professor for Teaching Student Thesis award (2021). Internationally, he has been named among the World's Top 2% Scientists by Stanford University and Elsevier in both 2023 and 2024. His expertise has also been acknowledged by the Korean Scientists and Engineers Network and the Korean Society for Cell Biology, where he received the Best Expert Award and Young Scientist Award. Prof. Son’s accomplishments highlight his dedication to scientific excellence, research leadership, and the mentoring of future scholars.
Dr. Mrinmoy Ghosh is a distinguished researcher specializing in molecular biology and computational biology, with a strong foundation in industrial biotechnology and genomics. He began his academic journey as a Postdoctoral Research Fellow at Jeju National University, South Korea, where he has been instrumental in advancing research at the intersection of omics technologies and nanomedicine. His pioneering work focuses on the development of nanotechnology-based microRNA (miRNA) therapeutics for the treatment of osteoarthritis, driven by cutting-edge applications of Next Generation Sequencing (NGS). With deep expertise in genomic analysis and systems biology, Dr. Ghosh is adept at decoding complex biological pathways and extracting actionable insights from high-dimensional data. His research is closely aligned with the missions of major scientific institutions such as the National Research Foundation of Korea (NRF) and the Research Institute for Basic Sciences (RIBS), contributing to interdisciplinary projects aimed at therapeutic innovation. Dr. Ghosh's contributions to science have been recognized with the prestigious Brain Pool Program award in 2022, granted by the Ministry of Science and ICT through the NRF of South Korea. His proficiency in computational biology and dedication to translational research continue to position him as a valuable contributor to the global biomedical research community.
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