Gas Chromatography-Mass Spectrometry for Omics Applications

Modern strategies of chemical analysis for molecular sample characterization using both targeted and non-targeted approaches

Gas Chromatography-Mass Spectrometry for Omics Applications explores the subject of integrated analytical strategies around gas chromatography and mass spectrometry (GC-MS) for sample chemical characterization. The book walks through the full analytical workflow, from sample preparation to the type of GC separation and MS hyphenation, how to ensure analytical quality and how to analyze and interpret the resulting data.

The first section provides foundations of key areas like non-targeted and targeted analyses, sample preparation, separation and detection, data management and interpretation, and quality control. The second section focuses on these tools’ applied use, including metabolomics, plants, environmental contaminants, and the study of refined samples for industrial processes.

Gas Chromatography-Mass Spectrometry for Omics Applications includes insights on:

• Definitions and concepts for targeted and non-targeted chemical analysis, GC-suited sample preparation approaches for omics studies, and principles of high-resolution and hyphenated GC-MS and GC×GC-MS
• Basic principles of mass spectrometry, management and interpretation of GC and MS detailed data, system suitability and quality control in GC-MS and GC×GC-MS, considering both low and high-resolution MS
• Sampling and analysis of specialized metabolites in humans for diagnostic, prognostic, and monitoring purposes
• In-vivo and in-situ analysis of plant volatilome and specialized metabolites in biological systems
• Environmental and individual impact of pollution and contaminants and markers of quality, authenticity, safety in processed food samples
• Detailed compositional analysis of refinery products and plastic chemical recycling

With contributions from the top experts in the field, Gas Chromatography-Mass Spectrometry for Omics Applications is an excellent up-to-date reference for analytical chemists involved in food, environmental, petrochemical, biological, industrial, clinical, and other fields where GC-MS is a key analytical tool for the detailed chemical composition for routine and advanced analysis.