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Tumour Necrosis Factor and Related Cytotoxins

Tumour Necrosis Factor and Related Cytotoxins

Gregory R. Bock, Joan Marsh

Wiley
Collection: Novartis Foundation Symposia
Publication date : 2008-04-30

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The number of factors implicated in the regulation of cell proliferation and differentiation is already considerable and more are continually being identified. This book concentrates on tumor necrosis factor (cachectin) and lymphotoxin, but includes observations of their interactions with other cytokines, especially the interferons and interleukins. TNF can be either cytostatic or cytotoxic to cultured cell lines, and a variety of mechanisms are proposed, ranging from DNA fragmentation to activation of phospholiopases. TNF is also reported to stimulate the growth of normal fibroblasts in vivo. The in vivo actions of TNF described here include haemorrhagic necrosis of tumors, cachexia, effects on the vasculature, and antiparasitic and antiviral activities. Also presented is some interesting data from the first stages of clinical trials of TNF as an anticancer agent.

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About the book

Author

Gregory R. Bock , Joan Marsh

Imprint

Wiley

Collection

Novartis Foundation Symposia

Publication date

2008-04-30

Pages

252 pages

Print ISBN

9780471910978

Language

English

Ebook informations

EAN PDF

9780470513538

Price

£108.61

Copy count 0

Print count 252

File size 12943 Ko

Informations accessibility

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About author(s)

Gregory R. Bock

Joan Marsh

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