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Decoding the Genomic Control of Immune Reactions

Decoding the Genomic Control of Immune Reactions

Novartis Foundation Symposium, Number 281

Gregory R. Bock, Jamie A. Goode

Wiley
Collection: Novartis Foundation Symposia
Publication date : 2007-04-04

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This book explores existing and potential strategies for using the genome sequences of human, mouse, other vertebrates and human pathogens to solve key problems in the treatment of immunological diseases and chronic infections. The assembled genome sequences now provide important opportunities for solving these problems, but a major bottleneck is the identification of key sequences and circuits controlling the relevant immune reactions. This will require innovative, interdisciplinary and collaborative strategies of a scale and complexity we are only now beginning to comprehend.

Specific problems addressed include the following:

What kinds of information are we lacking to understand how the genome sequence specifies the differentiation and response of immune system cells, and system behaviour such as immunological memory and tolerance?
Which genome sequences and cellular circuits cause or prevent pathological immune responses to foreign pathogens, allergens or self-tissues?
Which host and pathogen genome sequences and cellular circuits explain the failure of sterilizing immune responses to sophisticated human pathogens such as the agents of tuberculosis, malaria, metazoan parasites and chronic viruses?

Containing contributions from a range of leading experts in the field, this book provides an important new perspective for clinical immunologists and basic researchers alike.

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About the book

Author

Gregory R. Bock , Jamie A. Goode

Imprint

Wiley

Collection

Novartis Foundation Symposia

Publication date

2007-04-04

Pages

232 pages

Print ISBN

9780470027554

Language

English

Ebook informations

EAN PDF

9780470062111

Price

£166.64

Copy count 0

Print count 232

File size 8684 Ko

Informations accessibility

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About author(s)

Gregory R. Bock

Jamie A. Goode

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