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Myeloid-Derived Suppressor Cells and Cancer

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Myeloid-Derived Suppressor Cells and Cancer

Collectif

Springer
Collection: SpringerBriefs in Immunology
Publication date : 2016-03-15

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The book starts with an introduction to and history of myeloid-derived suppressor cells (MDSCs), followed by a description of their differentiation, their role in the tumour microenvironment and their therapeutic targeting. It closes with an outlook on future developments. In cancer patients, myelopoiesis is perturbed and instead of generating immunogenic myeloid cells (such as dendritic cells, inflammatory macrophages and granulocytes), there is an increase in highly immature MDSCs. These cells are distributed systemically, resulting in general immunosuppression. They also infiltrate tumours, promoting their progression and metastasis by inhibiting the natural anti-tumour immune response. As these cells also interact with classical anti-neoplastic treatments, they have become major therapeutic targets in the pharmaceutical industry and in oncology research.

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About the book

Author

Collectif

Imprint

Springer

Collection

SpringerBriefs in Immunology

Publication date

2016-03-15

Pages

102 pages

Print ISBN

9783319268194

Language

English

Ebook informations

EAN PDF

9783319268217

Price

£44.99

Copy count 1

Print count 10

File size 1966 Ko

Informations accessibility

EAN EPUB

9783319268217

Price

£44.99

Copy count 1

Print count 10

File size 758 Ko

Informations accessibility

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