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Stereoselective Heterocycle Synthesis via Alkene Difunctionalization

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Stereoselective Heterocycle Synthesis via Alkene Difunctionalization

Bulky Phosphine Ligands Enable Pd-Catalyzed Arylhalogenation, Arylcyanation and Diarylation

David A. Petrone

Springer
Collection: Springer Theses
Publication date : 2018-04-02

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This book investigates the use of palladium modified by bulky ligands as catalysts for new chemical transformations that rapidly assemble several classes of complex heterocyles. It documents the development of new chemical reactions involving carbon–carbon (C?C) and carbon–halogen (C?X) bond formation in the context of alkene difunctionalization and dearomatization reactions. Due to the ubiquity of heterocycles in bioactive natural products and life-improving pharmaceutical treatments, a long-term goal for synthetic organic chemists has been to develop novel and creative heterocycle syntheses that illicit a high degree of product diversity and are characterized by mild reaction conditions and limited waste production. A considerable fraction of leading pharmaceutical drugs contain at least one heterocycle within their chemical structure, and their prevalence in these technologies is strong evidence that the fundamental curiosities of organic chemistry lead to real-world solutions for the health and wellness of the global population.

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About the book

Author

David A. Petrone

Imprint

Springer

Collection

Springer Theses

Publication date

2018-04-02

Pages

365 pages

Print ISBN

9783319775067

Language

English

Ebook informations

EAN PDF

9783319775074

Price

£109.50

Copy count 3

Print count 36

File size 36475 Ko

Informations accessibility

EAN EPUB

9783319775074

Price

£109.50

Copy count 3

Print count 36

File size 4925 Ko

Informations accessibility

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About author(s)

David A. Petrone

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