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Epigenetic modification of cellular genomes is a fascinating means of regulating tissue- and cell type-specific gene expression in all developmental stages of the life of an organism. Carefully orchestrated processes, such as DNA methylation and a plenitude of specific...
The book presents the latest developments in clinical medicine, particularly involved with pulmonary care and diseases. Emphasis is placed on the role of childhood obesity, often a result of the ill effects of an unhealthy diet and nutritional deficits, in shaping...
Respiratory function is a major determinant of the overall quality of health and well-being of an individual. This book runs the gamut of chapters devoted to chronic cough-related conditions in children and adults, health care quality and safety, environmental pollution...
This book offers a comprehensive overview of current challenges and strategies to regenerate load-bearing and calcified human tissues, including bone, cartilage,tendon, ligaments and dental structures (dentin, enamel, cementum and periodontal ligament). Tissue...
This book highlights advances and prospects of a highly versatile and dynamic research field: Therapeutic ultrasound. Leading experts in the field describe a wide range of topics related to the development of therapeutic ultrasound (i.e., high intensity focused...
Every three years, the International Society for Arterial Chemoreception (ISAC) arranges a Meeting to bring together all of the major International research groups investigating the general topic of oxygen sensing in health and disease, with a prime focus upon systemic...
Diseases of the respiratory system often cause multisystem dysfunction and morbidity. Respiratory diseases not transmissible by a direct contact are rarer than those of inflammatory or infectious background. Such noncommunicable diseases, often entailing genetic and...
?Protein conversion from a water-soluble native conformation to the insoluble aggregates and fibrils, which can deposit in amyloid plaques, underlies more than 20 human diseases, representing a major public health problem and a scientific challenge. Such a conversion is...
This edited volume concerns a group of devastating neurological disorders that share a common pathological mechanism, namely the aggregation and deposition of insoluble, proteinaceous lesions, termed ‘amyloid’. Examples of cerebral amyloid disorders include common...
The respiratory tract is a frequent target of infections caused by a wide range of organisms.The book provides reader-friendly information on aspects of pulmonary infections, including comprehensive accounts of bacterial and viral diseases, therapeutic approaches,...
In collaboration with the Breast Cancer Research Foundation (BCRF), this timely volume provides a comprehensive review on all areas of breast cancer survivorship research, highlighting research that is underway or in development. The range of topics covered include the...
This book describes in 13 chapters mechanisms of P450 used to monooxygenate substrates via the NAD(P)H/O2 pathway using its peroxidase and peroxygenase functions. P450 also utilizes peroxides, peracids, periodate and iodosobenzene to oxygenate substrates via the shunt...
The book considers signaling events from the zygote embryo through to the blastocyst with relevant data from embryonic stem (ES) cells, including dialogue with the extracellular environment and with the maternal tract during the implantation process. Application of the...
The release of the complete version of the human genome sequence in 2003 has paved the way for defining gene function and genetic background for phenotypic variation in humans and allowed us to study the aging process in a new light. This new volume results from that...
The book blends basic and clinical research on respiratory carcinogensis.The contributions tackle a variety of respiratory-related cancers, notably non-small cell lung carcinoma, pleural mesothelioma, mediastinal tumors, or larynx cancer.The focus is on the search for...
This volume presents the most current reviews on how cancer stem cells (CSCs) hypothesis dictates that the continued proliferation of a tumor is dependent on a sub-population of self-renewing and asymmetrically dividing neoplastic stem cells that supply a largely...
This book centers on gene therapy and gene transfer approaches to prevent or treat chronic virus infections. The main focus is on the Big Three: human immunodeficiency virus (HIV-1), hepatitis B virus (HBV) and hepatitis C virus (HCV). Ample anti-HIV drugs are...
The blood system is multi-scale, from the organism to the organs to cells to intracellular signaling pathways to macromolecule interactions. Blood consists of circulating cells, cellular fragments (platelets and microparticles), and plasma macromolecules. Blood cells...
Recent Advances in Prolactin Research summarizes the current knowledge of prolactin (PRL), PRL receptor, PRL-dependent signaling pathways, the role of PRL in oncogenesis and PRL crosstalk with other oncogenic factors. The chapters are written by experts in these fields...
The dynamics of body metabolism are changed in the disease process and interact with physical activity.The alteration of metabolism and its consequences raise the need for simple and reliable methods for assessment of body composition.The chapters aim to investigate...
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