Increasing the Therapeutic Ratio of Radiotherapy eBook
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Increasing the Therapeutic Ratio of Radiotherapy

Kevin Camphausen, Philip J. Tofilon

  • Humana

  • Publication date : 2016-11-21

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Current cancer therapies are focused on three general strategies: modifying intrinsic radiosensitivity via molecular targeting, manipulating microenvironmental factors to enhance tumor susceptibility to radiation, and improving delivery of radiation to critical tumor locations while sparing normal tissues. The goal of this volume is to describe a number of promising approaches corresponding to each strategy.

In general, research in radiation oncology tends to be siloed into fundamental biology, physics or treatment delivery. The strategies for improving therapeutic ratio encompassed in this book will involve each of these components of radiation oncology. Thus, they will illustrate the variety of disparate approaches available for potentially improving the efficacy of radiotherapy, which may then stimulate discussion across disciplines and foster further translational investigations.

Although a goal of each chapter will be to highlight advances within an approach, of equal importance will be the delineation of barriers to successful clinical application and how to overcome or minimize such impediments. Along these lines, because therapeutic ratio incorporates both tumor and normal tissue radio response, a point of emphasis will be the mechanistic rationale for selectively modifying tumor (sensitization) or normal cells (protection).

Finally, whereas the literature is replete with studies describing potential targets/strategies for increasing the therapeutic ratio for radiotherapy, this book will focus on those supported by in vivo data consistent with impending translational application along with those that are already being evaluated in the clinic.

About the book
Author
Kevin  Camphausen , Philip J.  Tofilon
Imprint
Humana
Collection
n.c
Publication date
2016-11-21
Pages
280 pages
Print ISBN
9783319408521
Language
English
Ebook informations
EAN PDF
9783319408545
Price
£129.50
Read more
Copy count 2
Print count 28
File size 6840 Ko
Ce livre est accessible aux handicaps   Informations accessibility
EAN EPUB
9783319408545
Price
£129.50
Read more
Copy count 2
Print count 28
File size 2734 Ko
Ce livre est accessible aux handicaps   Informations accessibility
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Philip J. Tofilon, Ph.D., is Senior Investigator, Radiation Oncology Branch, National Cancer Institute. Kevin Camphausen, MD, is Branch Chief, Senior Investigator, Radiation Oncology Branch, National Cancer Institute.

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