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Molecular Neurosurgery with Targeted Toxins

Molecular Neurosurgery with Targeted Toxins

Douglas A. Lappi, Ronald G. Wiley

Humana
Publication date : 2007-10-10

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Pioneers and leading researchers explain the theory and techniques of using targeted toxins experimentally. The highly successful use of the 192 IgG-saporin and ME20.4-saporin immunotoxins to lesion the cholinergic basal forebrain in order to model the behavior, anatomy, physiology, and pharmacology of Alzheimer's disease in animals is treated in detail to give a potential user the knowledge to comfortably use the techniques involved. The uses of important new lesioning agents such as anti-DBH-saporin immunotoxin to make remarkably selective lesions of catecholaminergic neurons, hypocretin-saporin that can produce narcoleptic animals, and other saporin conjugates, such as neuropeptide-saporin conjugates for pain research and cholera toxin B chain-saporin to produce a model of CNS demyelination are explained by experts in the field.

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About the book

Author

Douglas A. Lappi , Ronald G. Wiley

Imprint

Humana

Collection

n.c

Publication date

2007-10-10

Pages

312 pages

Print ISBN

9781588291998

Language

English

Ebook informations

EAN PDF

9781592598960

Price

£109.50

Copy count 3

Print count 31

File size 3359 Ko

Informations accessibility

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About author(s)

Douglas A. Lappi

Ronald G. Wiley

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