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This book shares the latest findings on exercise and its benefits in preventing and ameliorating numerous diseases that are of worldwide concern. Addressing the role of exercise training as an effective method for the prevention and treatment of various disease, the...
This book contains twelve chapters contributed by prestigious international experts who are at the forefront of B cell research, and aims to provide a cutting-edge and comprehensive overview of all aspects of B cells, including B cell development, maturation and...
This book aims to introduce the latest research in gut microbiota by systematically summarizing how it modulates the pathogenesis of organ injury including alimentary tract injury, liver injury, lung injury, brain injury, renal injury, heart and vascular injury,...
This book is aimed to summarise the key aspects of the role of circulating tumour cells (CTCs) in breast cancer, with special attention to their contribution to tumour progression and establishment of metastatic disease. We aim to give a clear overview of the knowledge...
This book focuses on the use of animal models to study various human defects. It summarizes our current understanding of a variety of common human birth defects and the essential role of animal models in shedding light on the underlying mechanisms of these disorders....
Immunotherapy is a rapidly evolving field that mandates frequent revision of the book as new insights to fight cancer emerge. The third edition of Immunotherapy is an updated overview of immuno-oncology in different cancer types and toxicities associated with...
Protein homeostasis, or “Proteostasis”, lies at the heart of human health and disease. From the folding of single polypeptide chains into functional proteins, to the regulation of intracellular signaling pathways, to the secreted signals that coordinate cells in tissues...
This book presents the latest research on non-coding RNAs in cardiovascular disease, a major cause of death worldwide. Non-coding RNAs play a significant role in development, proliferation, differentiation and apoptosis. Since altered non-coding RNA expression is often...
Written by internationally recognized leaders in Heparanase biology, the book’s eight chapters offer an opportunity for scientists, clinicians and advanced students in cell biology, tumor biology and oncology to obtain a comprehensive understanding of Heparanase’s...
This book, written by members of the European network PROTEOSTASIS, provides an up-to-date review of the research regarding protein homeostasis in health and disease. With new discoveries contributing to the increasing complexity of this topic, the book offers a...
Revealing essential roles of the tumor microenvironment in cancer progression, this volume focuses on the extracellular matrix components of the tumor during cancer development. Further, it teaches readers about the roles of distinct constituents of the tumor...
This book provides an overview of the etiology of coronary artery disease and focuses on the main therapies and drug interventions currently available. It highlights drug pharmacology and therapeutic challenges, with a special emphasis on the underlying principles of...
This book systematically reviews the most important findings on cancer immune checkpoints, sharing essential insights into this rapidly evolving yet largely unexplored research topic. The past decade has seen major advances in cancer immune checkpoint therapy, which has...
This book systemically presents the latest research on lectins, covering all the major topics in the field, including the heterocomplex of lectins and Toll-like receptors, protective versus pathogenic functions in connection with microbial infections, and novel...
The way a cell undergoes malignant transformation should meet their capacity of surviving in the microenvironment of the organ where the cancer will develop. Metabolic adaptation is for sure one of the criteria that must be accomplished, driven by metabolic plasticity...
This book addresses hot issues in the research and management of difficult-to-treat medical disorders that are commonly encountered, but for which the underlying mechanisms are often unknown.These include the adverse effects of hemodialysis and its biocompatibility in...
This book presents essential studies and cutting-edge research results on tau, which is attracting increasing interest as a target for the treatment of Alzheimer's disease. Tau is well known as a microtubule-associated protein that is predominantly localized in the...
This thoroughly revised second edition is an up-to-date overview of the current knowledge of Notch and Notch signaling in embryology and cancer. It summarizes the newest achievements on this topic from Notch’s flag-ship function in the development of the embryo and for...
The work is a collection of contributions resulting from R&D efforts originated from scientific projects involving academia, technological partners, and end-user institutions.The aim is to provide a comprehensive overview of robotics technology applied to Healthcare,...
Revealing essential roles of the tumor microenvironment in cancer progression, this book provides a comprehensive overview of the latest research on the role of chemokines in the tumor microenvironment. Each chapter focuses on the chemokines patterns of expression,...
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