All ebooks by Birkhäuser in PDF and EPUB

Chemokine Biology - Basic Research and Clinical Application

L. Gordon Letts , Bernhard Moser , Kuldeep Neote

Chemokines play an important role in recruiting inflammatory cells into tissues in response to infection and inflammation. They also play an important role in coordinating the movement of T-cells, B-cells and dentritic cells, necessary to generate an immune response...

Toll-like Receptors in Inflammation

Elizabeth Brint , Luke A.J. O'neill , Luke A.J. O'neill

A repertoire of 10 TLRs mediate the first response to all microbes that infect mammals. They are the long sought receptors for a wide range of microbial products. Notable examples include TLR4 which recognizes LPS from gram negative bacteria, TLR3 which recognizes viral...

Erythropoietins and Erythropoiesis

Steven Elliott , Mary A. Foote , Graham Molineux

Research on, and interest in, red blood cell formation spans several centuries and was thought to have peaked in the 1980s with the cloning of the eryth- poietin (EPO) gene. In the years subsequent to the cloning of EPO and its expression as a recombinant protein, much...

Aromatase Inhibitors

B.J.A. Furr

Many breast tumours are dependent upon oestrogen for their development and continued growth. Over the last 25 years hormone therapy has progressed from the irreversible destruction of endocrine glands to the use of drugs that reversibly suppress oestrogen synthesis or...

Cancer: Cell Structures, Carcinogens and Genomic Instability

Leon P. Bignold

This volume began with an invitation from the publishers to edit a volume of EXS on Cancer.This invitation undoubtedly derived from my articles in Cellular and Molecular Life Sciences in 2002 and 2003 on the relationships between the morphology, aetiology and...

Advances in Targeted Cancer Therapy

Richard M. Schultz

Turning up the Heat on Pain: TRPV1 Receptors in Pain and Inflammation

Keith R. Bley , Annika B. Malmberg

Despite tremendous advances in the understanding of the sensory nervous system which have accompanied the recent explosive growth of the neurosciences, rema- ably few innovative medicines directed towards pain and inflammation are ava- able. Indeed, many patients are...

The Grand Challenge for the Future

Stefan H.E. Kaufmann , Paul-Henri Lambert , Stefan H.E. Kaufmann

The most urgently needed vaccines are those against poverty-related diseases such as tuberculosis, malaria and HIV. However, there is a considerable gap between the development of a vaccine and the implementation as a useful measure for disease control. Major obstacles...

Sodium Channels, Pain, and Analgesia

Mark D. Baker , Kevin Coward

Sodium channels confer excitability on neurons in nociceptive pathways and exhibit neuronal tissue specific and injury regulated expression. This volume provides recent insights into the control of expression, functioning and membrane trafficking of nervous system...

Drugs for Relapse Prevention of Alcoholism

Karl F. Mann , Rainer Spanagel

Alcoholism is a pathological behavioural syndrome, characterised by comp- sive alcohol use, craving and relapses, even recurring after many years of abstinence. It is suggested that chronic alcohol abuse leads to persistent changes within several neurochemical pathways...

The NPY Family of Peptides in Immune Disorders, Inflammation, Angiogenesis, and Cancer

Giora Z. Feuerstein , Zofia Zukowska

Recent research indicates that the immune system and inflammatory reactions are governed and regulated by powerful neuronal mediators derived from the central and peripheral nervous system. The NPY family of peptides is a diverse group of neuropeptides that acts via...

Nimesulide - Actions and Uses

K. D. Rainsford

Nimesulide is a non-steroidal anti-inflammatory drug (NSAID) which acts as a cyclooxygenase- 2 inhibitor but also has other novel pharmacological features which account for its effect in the control of pain and inflammation. It has become a leading NSAID in over 50...

Köhler's Invention

Klaus Eichmann

Georges Köhler was one of the most prominent German scientists of recent history. In 1984, at an age of 38, he received the Nobel Prize in Physiology or Medicine, together with N.K. Jerne and C. Milstein, for inventing the technique for generating monoclonal antibodies....

Berichte zur Lebensmittelsicherheit 2013

Bvl

Zoonosen sind Krankheiten bzw. Infektionen, die auf natürlichem Weg direkt oder indirekt zwischen Menschen und Tieren übertragen werden können. Als Zoonoseerreger kommen Viren, Bakterien, Pilze, Parasiten oder Prionen in Betracht. Zoonoseerreger sind in Tierpopulationen...

Berichte zur Resistenzmonitoringstudie 2011/2012

N.C.

Die Anwendung von antibakteriell wirksamen Substanzen in der Veterinärmedizin erfolgt zum einen aus Gründen des Verbraucherschutzes, zum anderen zur Erhaltung der Tiergesundheit. Gleichzeitig führt jeder Einsatz von Antibiotika zur Selektion von bereits bestehenden...