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It was one of the great moments of humanity when Wilhelm Conrad Röntgen (1845– 1923) discovered a new kind of radiation on 8 November 1895. He himself modestly called them “X-rays”. Röntgen’s name and his rays became world famous. On 10 December 1901, Röntgen received...
This two-part volume gathers extended conference abstracts corresponding to selected talks from the "Biostatnet workshop on Biomedical (Big) Data" and from the "DoReMi LD-RadStats: Workshop for statisticians interested in contributing to EU low dose radiation research",...
This book reproduces and comments John Woodall’s handbook which was used as standard text for medical treatment at sea in the seventeenth century and was the first instruction for medical service aboard on the whole. In 1612 the East India Company, founded in London...
Both metabotropic and ionotropic glutamate receptors present attractive “druggable” targets in treating disorders of the central nervous system. There has been a dramatic shift in the focus of glutamate-based therapies away from neurologic disorders such as stroke and...
William Q. Meeker has made pioneering and phenomenal contributions to the general areaofreliabilityand,inparticular,tothetopicsofdegradationandacceleratedtesting. Hisresearchpublicationsandthenumerouscitationshehasreceivedoverthepastthree decades provide an ample...
This book describes the authors’ standard or ‘best’ practices used in writing regul- ed clinical documents for the drug and biologics industry. The fundamental premise of this book is that the end (documents submitted to a health authority) is dep- dent on the beginning...
The fifth volume of Birkhäuser Advances in Infectious Diseases is focused on pediatric infectious diseases. In modern medicine, the discipline pediatric infectious diseases is an important medical specialty.The successful prevention of childhood dise- es like...
Chemokines play an important role in recruiting inflammatory cells into tissues in response to infection and inflammation. They also play an important role in coordinating the movement of T-cells, B-cells and dentritic cells, necessary to generate an immune response...
Entry Inhibitors in HIV Therapy details the current status of this relatively new and very dynamic class of inhibitors, appealing to both the clinician and basic research scientist. A unique overview of obstacles and accomplishments is presented. The book features...
During recent years the field of effective anticancer agents has substantially increased. The use of chemotherapy has been accepted as a standard therapy for an expanding number of tumour types and stages, while many new agents are being investigated when standard...
Cognitive function involves the participation of many different neurotransmitter systems in a variety of brain areas. The centerpiece of investigation regarding cognitive function has classically been the cholinergic system, but it has become increasingly clear that...
In Vivo Models of Inflammation provides the biomedical researcher with a description of the state of the art animal model systems used to emulate diseases with components of inflammation. This second edition acts as a complement to the first edition by describing and...
Since the discovery of chemokines and of chemokine receptors it has become evident that expression of chemokines at the site of inflammation may regulate the composition of cellular infiltrate, thereby directing the type of immune response. Recently, the molecular...
Over the last decade, the advent of biologic agents has greatly revolutionized therapeutic medicine in the management of chronic inflammatory diseases, such as rheumatoid arthritis, Crohn’s disease, and psoriasis. Elucidation of the complex web of cytokine network and...
From the emergence of clinical sleep medicine marked by the establishment of the harbinger Stanford Sleep Disorders Clinic in the mid 1970s, offspring sleep dis- ders clinics and centers have grown exponentially with the recognition of the unmet diagnostic and treatment...
Regulatory T-cells are essential components of the immune system, and several different subsets of regulatory T-cells have been described. Considerable regulatory function has been attributed to the CD4+CD25+ T-cell subset. These cells act by suppressing adaptive and...
Although the potential for immunomodulation has been recognized for many years there has been an explosion of data in this field with relevance especially to the treatment of chronic airway diseases. Most of the work in this field has been conducted by Japanese...
It is with great pleasure that we introduce the first volume of Birkhäuser Advances in Infectious Diseases.This book series focuses on relevant and trending topics in microbiology and infectious diseases with emphasis on emerging pathogens and related diseases.This...
In recent years, cannabis research has concentrated on the potential of cannabinoids as therapeutic substances, particularly in serious chronic illnesses such as multiple sclerosis. Most volumes published on cannabinoids so far concentrate on the biological activity,...
The NPY-family of peptides encompasses several groups of neurotransmitters and hormones, which exert diverse biological and pathological actions that bear on all major vital systems.The recognition of the role of NPY in stimulation of food intake has already resulted in...
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