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The success of any drug discovery project relies upon the quality of the lead that initiates the lead optimization process. What defines a 'quality lead', where these 'quality leads' come from and how one discovers them has been the subject of intense debate within the...
In this book, we study theoretical and practical aspects of computing methods for mathematical modelling of nonlinear systems. A number of computing techniques are considered, such as methods of operator approximation with any given accuracy; operator interpolation...
The development of science, technology and industry in the near future requires new materials and devices, which will differ in many aspects from that of past years. This is due to the fact that many sophisticated processes and new materials are being invented.The...
The rotating shallow water (RSW) model is of wide use as a conceptual tool in geophysical fluid dynamics (GFD), because, in spite of its simplicity, it contains all essential ingredients of atmosphere and ocean dynamics at the synoptic scale, especially in its two- (or...
Superlubricity is defined as a sliding regime in which friction or resistance to sliding vanishes. It has been shown that energy can be conserved by further reducing/removing friction in moving mechanical systems and this book includes contributions from world-renowned...
Technological development has caused profound changes and social stability. Regions which have had stable populations for centuries have experienced enormous population growth leading to the emergence of sometimes unmanageable megaplex cities as well as bringing about...
In the past two decades there has been considerable work on global climatic change and its effect on the ecosphere, as well as on local and global environmental changes triggered by human activities. From the tropics to the Arctic, peatlands have developed under various...
Glaciotectonism is an important component of modern glacial theory, gaining widespread recognition within the past 25 years. This book is outcome of compiling maps of glaciotectonic structures and landforms for North America and central Europe, which is the basis for...
Eye-movement recording has become the method of choice in a wide variety of disciplines investigating how the mind and brain work. This volume brings together recent, high-quality eye-movement research from many different disciplines and, in doing so, presents a...
Hydrodynamic and pollutant transport models are useful tools for evaluating remediation options for polluted water bodies. These models span the range from highly theoretical, fine resolution, physically-based designs to lumped, black-box representations of real world...
This work covers effectively all aspects of drug-induced pathology that may be encountered within preclinical toxicity studies. It fills a gap in the pathology literature relating to the preclinical safety assessment of new medicines. It systematically describes, in one...
The increasing importance of nonwoven filter media is due in part to their versatility: they are used in the pre-filtration of liquids, protection of membrane filters, gaseous filtration, the automotive industry, air purification, wet filtration and many household uses....
Oxidative stress is the result of an imbalance in pro-oxidant/antioxidant homeostasis that leads to the generation of toxic reactive oxygen species. Brain cells are continuously exposed to reactive oxygen species generated by oxidative metabolism, and in certain...
Recent Progress in Mesostructured Materials is a selection of oral and poster communications presented during the 5th International Mesostructured Materials Symposium (5th IMMS2006). Authorized by International Mesostructured Material Association (IMMA) and hosted by...
Alkaloids, represent a group of interesting and complex chemical compounds, produced by the secondary metabolism of living organisms in different biotopes. They are relatively common chemicals in all kingdoms of living organisms in all environments. Two hundred years of...
The year 2007 marks the 300th anniversary of the birth of one of the Enlightenment's most important mathematicians and scientists, Leonhard Euler. This volume is a collection of 24 essays by some of the world's best Eulerian scholars from seven different countries about...
Systems biology is a vigorous and expanding discipline, in many ways a successor to genomics and perhaps unprecedented in its combination of biology with a great many other sciences, from physics to ecology, from mathematics to medicine, and from philosophy to...
The dictionary will contain terms currently used in the broad fields of electronics data protection and data management in today's interconnected world - the Global Village.The terminology will cover all aspects of the modern technology's best practices in multiple...
Computational elastohydrodynamics, a part of tribology, has existed happily enough for about fifty years without the use of accurate models for the rheology of the liquids used as lubricants. For low molecular weight liquids, such as low viscosity mineral oils, it has...
The Radioactivity in the Environment Series addresses the key aspects of this socially important and complex interdisciplinary subject. Presented objectively and with the ultimate authority gained from the many contributions by the world's leading experts, the negative...
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