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This volume presents state-of-the-art information on each of the arms of the unfolded protein response (UPR), how their activation/repression are regulated, integrated, and coordinated, how UPR components affect cancer cell biology and responsiveness to therapeutic...
This book discusses why specific diseases are being targeted for cell-based retinal therapy, what evidence exists that justifies optimism for this approach, and what challenges must be managed in order to bring this technology from the laboratory into routine clinical...
Although transgender persons have been present in various societies throughout human history, it is only during the last several years that they have become widely acknowledged in our society and their right to quality medical care has been established. In the United...
This book ventures into a new and exciting area of discovery that directly ties our current knowledge of cancer to the discovery of microorganisms associated with different types of cancers. Recent studies demonstrate that microorganisms are directly linked to the...
This book provides a concise yet comprehensive overview of minimally invasive gastrointestinal surgery, specifically for the medical internist. Organized by organ system, the text reviews the pathophysiology, workup, treatment, and surgical options for diseases inherent...
This unique book is a practical guide for the clinician faced with the challenge of diagnosing and managing neonates, infants and children with congenital hyperinsulinism (HI), within the framework of pathophysiology and molecular genetics. Major advances have been made...
This book provides an understanding of the challenges that individuals with Autism Spectrum Disorder (ASD) face in receiving medical care and helps equip medical professionals to overcome these challenges to provide high quality, compassionate medical care to this...
This book is a comprehensive guide to our current understanding of idiopathic pulmonary fibrosis (IPF), its disease pathogenesis, genetic underpinnings, diagnosis, and management. Since the first edition, many new developments have occurred in the understanding and...
This book connects experts in the field of child assessment to provide child psychiatrists with knowledge in evaluation and educational programming. The book provides a review of the latest science behind: common learning disabilities, including etiology and guidelines...
Fibroproliferative diseases are a broad spectrum of entities from organ-specific involvement (e.g., pulmonary, heart, liver, and kidney fibrosis) to multi-system diseases such as systemic sclerosis and sclerodermatous graft vs. host disease. These diseases also...
Major Depressive Disorder (MDD) is one of the most prevalent psychiatric disorders, with a lifetime prevalence rate of roughly 20%. MDD is a leading cause of disability and premature death worldwide, leads to greater impairment in work functioning than other chronic...
The discovery of ER by Dr. Elwood Jensen exactly 60 years ago has not only led to the birth of a whole new vital nuclear receptor research field but also made a rapid, direct and lasting impact on the treatment and prevention of breast cancer. Since that landmark...
This timely volume explores the impact of autophagy in various human diseases, emphasizing the cell biological aspects and focusing on therapeutic approaches to these diseases. The chapters cover autophagy and its potential applications on diseases ranging...
This book is a comprehensive and authoritative source on nontuberculous mycobacterial (NTM) pathogens and diseases and their appropriate management, with a focus on lung disease. NTM diseases, especially lung diseases, are increasing in prevalence in the U.S. and...
This proposed text is designed to provide a useful and comprehensive resource and state-of-the-art overview to readers about vascular damage potentially induced by antineoplastic drugs. Thanks to more and more effective antineoplastic treatments the survival...
This book addresses the unique sociocultural and historical systems of oppression that have alienated African-American and other racial minority patients within the mental healthcare system. This text aims to build a novel didactic curriculum addressing racism,...
This volume provides a concise yet comprehensive overview of gastrointestinal interventional radiology (IR). The text reviews the extensive array of gastrointestinal IR procedures available, while illustrating the ways in which IR can help and how IR may be the only...
In the fourth edition of this gold-standard title, a distinguished panel of experts provides a thorough update of the significant improvements in our understanding of diabetic foot physiology and its clinical management. Divided into three sections, the...
This indispensable volume highlights recent studies identifying epigenetic mechanisms as essential regulators of skin development, stem cell activity and regeneration. Chapters are contributed by leading experts and promote the skin as an accessible model system for...
This pocket guide provides a concise yet comprehensive overview of the pathogenesis, treatment, and management of Wilson disease. Drawing upon expertise from the Center of Excellence at Yale University in liver disease, neurology, and psychiatry for adult and pediatric...
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