CNS Cancer

Erwin G. Van Meir

Cancers of the central nervous system are among the most lethal of human neoplasms. They are recalcitrant to even intensive multimodality therapies that include surgery, radiotherapy, and chemotherapy. Moreover, especially in children, the consequences of these...

Stem Cells and Cancer

Rebecca G. Bagley , Beverly A. Teicher

Significance of Stem Cells to Tumor Development Cancer stem cells remain a controversial topic and the criteria that define cancer stem cells are continuing to evolve. A recent surge in stem cell research has ignited a field of discovery into many human diseases...

Pocket Handbook of GI Pharmacotherapeutics

Achilles Pappano , George Y. Wu

Although there are many pharmacology texts, and electronic sources of drug information relating to GI disorders, they are frequently encyclopedic, and practical information can be difficult to find. In Pocket Handbook of GI Pharmacotherapeutics, George Wu and Achilles...

Telomeres and Telomerase in Cancer

Keiko Hiyama

Telomerase, an enzyme that maintains telomeres and endows eukaryotic cells with immortality, was first discovered in tetrahymena in 1985. In 1990s, it was proven that this enzyme also plays a key role in the infinite proliferation of human cancer cells. Now telomere and...

Opiate Receptors and Antagonists

Edward J. Bilsky , Reginald Dean , S. Stevens Negus

The evolution in our understanding of opioid receptors and their subtypes is in- mately linked to the development of new pharmacological treatments for diseases/ disorders as diverse as addiction, self-injurious behavior, pain, cancer, infl- mation, eating disorders,...

Platinum and Other Heavy Metal Compounds in Cancer Chemotherapy

Andrea Bonetti , Stephen B. Howell , Roberto Leone , Franco Muggia

Cisplatin, the first member of the family of platinum-containing chemotherapeutic agents, was discovered by Barnett Rosenberg in 1965 and approved by the FDA for marketing in 1978. After 30 years of use in the clinic, cisplatin remains a central element of many...

Cardiac Safety of Noncardiac Drugs

Ihor Gussak , Joel Morganroth

Handbook of Drug Monitoring Methods

Amitava Dasgupta

In Handbook of Drug Monitoring Methods: Therapeutics and Drug Abuse, authors discuss the different analytical techniques used in today’s practice of therapeutic drug monitoring and drugs of abuse as well as alcohol testing with relevant theory, mechanism, and in-depth...