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From humble beginnings over 25 years ago as a lipid kinase activity associated with certain oncoproteins, PI3K (phosphoinositide 3-kinase) has been catapulted to the forefront of drug development in cancer, immunity and thrombosis, with the first clinical trials of PI3K...
PI3K has become a very intense area of research, with over 2000 publications onPI3K in PubMed for 2009 alone. The expectations for a therapeutic impact of intervention withPI3K activity are high, and progress in the clinical arena is being monitored by many. However,...
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