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The Evolution of Immunotherapy Against Tumors: An Historical Approach summarizes the literature concerning the development of the theory of immune surveillance against tumors. It discusses the evidence for and against this theory, along with the concept of...
Advances in Genetics serial, Volume 110 highlights new advances in the field, with this new volume presenting interesting chapters on a variety of timely topics, all written by an international board of authors. - Provides the authority and expertise of leading...
New Insights on the Development of the Vascular System examines the most recent literature and data on the development of the vascular system, along with advice on new laboratory techniques and approaches to data analysis. This volume is a comprehensive handbook to the...
The Vascular Endothelium: A Holistic Approach for Oncology provides novel and integrated knowledge on the endothelial cells as a crucial component involved in the growth of different organs in both physiological and pathological conditions. By covering diverse aspects...
Tumor Microenvironment Regulation ofTumor Expansion is a practical guide to understand and perform research on tumor microenvironments, and to support related clinical decisions. Tumor progression is linked to an imbalance between positive and negative regulators, and...
Tumor Vascularization discusses the different types of growth of tumor blood vessels and their implications on research and healthcare. The book is divided into three parts: the first one, General Mechanisms, discusses different vessel growth mechanisms, such as...
Mast cells (MC) are phylogenetically old cells which are distributed throughout the human organism. MC are found in almost all of the major organs and tissues of the body, particularly in association with connective tissue structures such as blood vessels, lymphatic...
The aim if this book is to analyze the scientific biography of Judah Folkman, one of the most important scientist of the last century. More 50 years ago, Folkman found a revolutionary new way to think about cancer. Blood supply, Folkman hypothesized, was the key to...
Immunology in the Twentieth Century: From Basic Science to Clinical Application grew out of common knowledge that those who survived many of the common infectious diseases rarely contracted the same disease again. This book charts the historical development of this...
This book is focused on the analysis of the role played by immune cell components in the angiogenic process associated with inflammation and tumor growth. Both innate and adaptive immune cells are involved in the mechanisms of endothelial cell proliferation, migration...
In Vivo Models to Study Angiogenesis provides the latest information and an overview of the most common assays for studying angiogenesis in vivo. Under physiological conditions, angiogenesis is tightly controlled, whereas increased production of angiogenic stimuli...
Milestones in Immunology: Based on Collected Papers contains scientific milestones relating to the history of medicine over the past two centuries. The book highlights the contributions of pioneering scientists whose discoveries have paved the way for researchers...
In spite of their relatively low prevalence, systemic vasculitides have been the object of intensive basic and clinical investigations over the last few years. As a consequence, important advancements have been achieved: from updated diagnostic and classification...
This work describes the importance of tumor microenvironment in favouring tumor progression and angiogenesis.Under physiological conditions, angiogenesis is dependent on the balance of positive and negative angiogenic modulators within the vascular microenvironment and...
This book traces significant aspects of the history of immunology, exploring the immune system and immunodeficiency. The author recounts human hematopoietic development, and how a distinction of the immune system into thymus-dependent and thymus-independent components...
It has been generally accepted that angiogenesis is involved in the pathogenesis of hematological malignancies, like acute and chronic leukemia, lymphoma, myelodysplastic syndromes, myeloproliferative neoplasms and multiple myeloma. The extent of angiogenesis in the...
Blood vessels of tumors display many structural and functional abnormalities. Their unusual leakiness, potential for rapid growth and remodeling, and expression of distinctive surface molecules mediate the dissemination of tumor cells in the bloodstream and maintain the...
Mast cells are versatile, tissue-homing secretory cells, which were first described by Paul Ehrlich in 1878.Mast cells have long been implicated in the pathogenesis of allergic reactions and certain protective responses to parasites. Their functional role, however, has...
The study of medical history is interesting in itself and may help to modify the view sometimes expressed that medical students and doctors are lacking in culture of any sort. Moreover, some historical perspective is often advantageous when one is considering the...
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