All ebooks in the collection "Research and Perspectives in Alzheimer's Disease" - Springer

Proteopathic Seeds and Neurodegenerative Diseases

Yves Christen , Mathias Jucker

The misfolding and aggregation of specific proteins is an early and obligatory event in many of the age-related neurodegenerative diseases of humans.The initial cause of this pathogenic cascade and the means whereby disease spreads through the nervous system, remain...

Protein Quality Control in Neurodegenerative Diseases

Yves Christen , Richard I. Morimoto

The health of the proteome depends upon protein quality control to regulate the proper synthesis, folding, translocation, and clearance of proteins.The cell is challenged constantly by environmental and physiological stress, aging, and the chronic expressions of disease...

Two Faces of Evil: Cancer and Neurodegeneration

Yves Christen , Thomas Curran

Homeostasis involves a delicate interplay between generative and degenerative processes to maintain a stable internal environment. In biological systems, equilibrium is established and controlled through a series of negative feedback mechanisms driven by a range of...

Diabetes, Insulin and Alzheimer's Disease

Suzanne Craft

Alzheimer: 100 Years and Beyond

Konrad Beyreuther , Christian Haass , Mathias Jucker , Roger M. Nitsch

Few medical or scientific addresses have so unmistakeably made history as the presentation delivered by Alois Alzheimer on November 4, 1906 in Tübingen. The celebratory event, "Alzheimer 100 Years and Beyond" organized on the initiation of the Alzheimer community in...

Genotype - Proteotype - Phenotype Relationships in Neurodegenerative Diseases

J. Cummings , J. Hardy , M. Poncet

Recent advances in understanding the role of protein dysmetabolism in neurodegeneration was the theme of the Fondation IPSEN meeting addressing Genotype-Proteotype-Phenotype relationships. Experts from international laboratories contributed to the  current...